約氏乳桿菌

Lactobacillus johnsonii    LBJ456^?     菌株典藏編碼：M20191013

【功能性/Effects】

減少系統(tǒng)性炎癥

降低基因毒性

【作用機(jī)理/Mechanism of Action】

減少宿主體內(nèi)促炎性細(xì)胞因子IL-1β和IFN-β水平，同時提高抗炎細(xì)胞因子TGFβ和IL-10水平，從而減少系統(tǒng)性炎癥的發(fā)生，進(jìn)而減少基因毒性。

【參考文獻(xiàn)/References】

1. Cancer risk reduction through active management of genotoxicity

2.Intestinal inflammation induces genotoxicity to extraintestinal tissue and cell types in mice

3.A novel probiotic, Lactobacillus johnsonii 456, resists acid and can persist in the human gut beyond the initial ingestion period